Liposomal Encapsulation Technology (LET) is the use of a structure (a liposome) to carry and deliver active ingredients.
Liposomes are nano-sized spheres whose composition is the same as cellular membranes. They are filled with the active ingredient that needs to be delivered to the body. Acting as a protective layer for the substance incapsulated within it, this type of technology solves problems linked to oxidation, denaturation, and the instability of active ingredients that aren’t encapsulated. The benefits of LET are numerous and vary according to the field of application.
oral liposomes ensure that the encapsulated ingredient passes through the GI tract whole and unaltered, without any metabolic changes, notably increasing its efficacy and bioavailability.
liposomes ensure that the encapsulated active ingredient remains in the anterior segment of
In this case, the main role of the liposome is to bind to the surface of the cornea and improve residence time.
One practical application of this technology could be its use in eye drops, seeking to increase the time in which the formula stays in the eye, thereby slowing the rate of tear drainage.
The word ‘liposome’ refers to a set of lipidic particles arranged in a structure
similar to that of cellular membranes.
They are mainly made up of a double layer of phospholipids that, thanks to the way they are positioned, make it possible to encapsulate active ingredients within their ‘shell’, called a vesicle. They’re manufactured in specialized laboratories with cutting-edge technology.